KMID : 0616120100410010043
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Korean Journal of Pharmacognosy 2010 Volume.41 No. 1 p.43 ~ p.47
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Screening on Receptor Tyrosine Kinase Inhibitory Activity of Marine Algae-Derived Symbiotic Microorganisms
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Yun Keum-Ja
Yang Guo-Hua Feng Zhile Nenkep Viviane N. Siwe-Noundou Xavier Leutou Alain S. Kim Kun-Do Cho Hee-Yeong Choi Hong-Dae Son Byeng-Wha
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Abstract
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In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at 10 ¥ìg/ml) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with IC50 values of 0.6 and 0.9 ¥ìg/ml, respectively.
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KEYWORD
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Marine algae, Symbiotic marine microorganism, Receptor tyrosine kinase (RTK) inhibitor, Antitumor drug lead
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